Khalil, S., Weshah, K., EI-Sayed, W. (2004). THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.. Journal of Soil Sciences and Agricultural Engineering, 29(3), 1573-1587. doi: 10.21608/jssae.2004.240846
Samia M.l. Khalil; K. Weshah; W. EI-Sayed. "THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.". Journal of Soil Sciences and Agricultural Engineering, 29, 3, 2004, 1573-1587. doi: 10.21608/jssae.2004.240846
Khalil, S., Weshah, K., EI-Sayed, W. (2004). 'THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.', Journal of Soil Sciences and Agricultural Engineering, 29(3), pp. 1573-1587. doi: 10.21608/jssae.2004.240846
Khalil, S., Weshah, K., EI-Sayed, W. THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.. Journal of Soil Sciences and Agricultural Engineering, 2004; 29(3): 1573-1587. doi: 10.21608/jssae.2004.240846
THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.
1Biochem. Dept., Faculty of Agric., Minufiya Univ., Egypt.
2Plant Protect. Dept.,Faculty of Agric.,Aln Shams Univ., Egypt.
Abstract
The present study concerns the evaluation of chlorpyrifos, and cypermethrin toxicity on acetylcholinesterase, transaminases and phosphatases activities in male albino rats. In addition, the protective effect of ascorbic acid (Vitamine C) against the toxicity induced by the examined insecticides were studied. Results indicated a significant inhibition in the acetylcholinesterase (AChE) activity in serum, liver and brain within two days to 29.43, 36.96 and 26.43% by chlorpyrifos and to 58.34,62.34 and 67.39% by cypermethrin in the three organs, respectively. Recovery of AChE was observed after 4 days from treatment by both insecticides. However, treament by ascorbic acid with chlorpyrifos reduced the inhibition, where the activity reached 48.46, 46.88 and 36.00%, while ascorbic acid with cypermethrin the activity reached 78.63, 71.25 and 75.24% in the three organs, respectively. The activities of aspartate transaminase (AST), alanine transaminase (AL T), alkaline phosphatase (ALP) and acid phosphatase (AP) were significantly increased throughout experimental periods upon treatment by both insecticides. Ascorbic acid also depressed the elevated activities of AST, AL T ALP and AP upon treatment with the examined insecticides. The residues and coefficient of distribution (COT) of the tested insecticides were determined in blood, brain, liver, kidney, heart and lung and the results were consistant with the remaining activities of the examined enzymes.