THE PROTECTIVE EFFECT OF ASCORBIC ACID AGAINST TOXICITY INDUCED BY CHLORPYRIFOS AND CYPERMETHRIN ON ACETYLCHOLINESTERASE, TRANSAMINASES AND PHOSPHATASES ACTIVITIES IN ALBINO RATS.

Document Type : Original Article

Authors

1 Biochem. Dept., Faculty of Agric., Minufiya Univ., Egypt.

2 Plant Protect. Dept.,Faculty of Agric.,Aln Shams Univ., Egypt.

Abstract

The present study concerns the evaluation of chlorpyrifos, and
cypermethrin toxicity on acetylcholinesterase, transaminases and
phosphatases activities in male albino rats. In addition, the protective effect
of ascorbic acid (Vitamine C) against the toxicity induced by the examined
insecticides were studied. Results indicated a significant inhibition in the
acetylcholinesterase (AChE) activity in serum, liver and brain within two
days to 29.43, 36.96 and 26.43% by chlorpyrifos and to 58.34,62.34 and
67.39% by cypermethrin in the three organs, respectively. Recovery of AChE
was observed after 4 days from treatment by both insecticides. However,
treament by ascorbic acid with chlorpyrifos reduced the inhibition, where the
activity reached 48.46, 46.88 and 36.00%, while ascorbic acid with
cypermethrin the activity reached 78.63, 71.25 and 75.24% in the three
organs, respectively. The activities of aspartate transaminase (AST), alanine
transaminase (AL T), alkaline phosphatase (ALP) and acid phosphatase (AP)
were significantly increased throughout experimental periods upon treatment
by both insecticides. Ascorbic acid also depressed the elevated activities of
AST, AL T ALP and AP upon treatment with the examined insecticides. The
residues and coefficient of distribution (COT) of the tested insecticides were
determined in blood, brain, liver, kidney, heart and lung and the results were
consistant with the remaining activities of the examined enzymes.

Keywords

Journal of Soil Sciences and Agricultural Engineering
Volume 29, Issue 3
March 2004
Pages 1573-1587

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